WIPF2

WIPF2
Identifiers
Aliases	WIPF2, WICH, WIRE, WAS/WASL interacting protein family member 2
External IDs	MGI: 1924462 HomoloGene: 15777 GeneCards: WIPF2
Gene ontology Molecular function • actin filament binding • actin binding • protein binding Cellular component • cytoplasm • actin cortical patch • cytosol • cytoskeleton • actin filament Biological process • endocytosis • actin cortical patch assembly • actin filament-based movement • Fc-gamma receptor signaling pathway involved in phagocytosis • positive regulation of actin nucleation • actin cortical patch localization • regulation of cell shape Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	147179	68524
Ensembl	ENSG00000171475	ENSMUSG00000038013
UniProt	Q8TF74	Q6PEV3
RefSeq (mRNA)	NM_133264	NM_197940
RefSeq (protein)	NP_573571.1	NP_922922.1
Location (UCSC)	Chr 17: 40.22 – 40.28 Mb	Chr 11: 98.86 – 98.91 Mb
PubMed search	[1]	[2]
Wikidata

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WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.^[3][4][5]

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Aspenstrom P (Sep 2002). "The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor". Exp Cell Res. 279 (1): 21–33. doi:10.1006/excr.2002.5576. PMID 12213210.
4. Kato M, Miki H, Kurita S, Endo T, Nakagawa H, Miyamoto S, Takenawa T (Feb 2002). "WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation". Biochem Biophys Res Commun. 291 (1): 41–7. doi:10.1006/bbrc.2002.6406. PMID 11829459.
5. "Entrez Gene: WIPF2 WAS/WASL interacting protein family, member 2".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.