XAB2

XAB2
Identifiers
Aliases	XAB2, HCNP, HCRN, NTC90, SYF1, XPA binding protein 2
External IDs	MGI: 1914689 HomoloGene: 5738 GeneCards: XAB2
Gene ontology Molecular function • protein binding Cellular component • prespliceosome • catalytic step 2 spliceosome • membrane • catalytic step 1 spliceosome • post-mRNA release spliceosomal complex • Prp19 complex • nucleoplasm • spliceosomal complex • nucleus Biological process • mRNA splicing, via spliceosome • RNA processing • mRNA processing • transcription, DNA-templated • generation of catalytic spliceosome for first transesterification step • cellular response to DNA damage stimulus • RNA splicing • cerebral cortex development • transcription-coupled nucleotide-excision repair • blastocyst development • DNA repair Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56949	67439
Ensembl	ENSG00000076924	ENSMUSG00000019470
UniProt	Q9HCS7	Q9DCD2
RefSeq (mRNA)	NM_020196	NM_026156
RefSeq (protein)	NP_064581.2	NP_080432.1
Location (UCSC)	Chr 19: 7.62 – 7.63 Mb	Chr 8: 3.61 – 3.62 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Pre-mRNA-splicing factor SYF1 is a protein that in humans is encoded by the XAB2 gene.^[3][4]

Interactions

XAB2 has been shown to interact with ERCC8^[3] and XPA.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (Nov 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. 275 (45): 34931–7. doi:10.1074/jbc.M004936200. PMID 10944529.
4. "Entrez Gene: XAB2 XPA binding protein 2".

Further reading

• Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.