ZMYND11

ZMYND11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NS5, 5HDA
Identifiers
Aliases	ZMYND11, BRAM1, BS69, MRD30, zinc finger MYND-type containing 11
External IDs	MGI: 1913755 HomoloGene: 4828 GeneCards: ZMYND11
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription corepressor activity • histone binding • zinc ion binding • chromatin binding • transcription cofactor activity • metal ion binding • methylated histone binding • protein binding Cellular component • nucleoplasm • chromosome • nucleus Biological process • regulation of transcription, DNA-templated • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of transcription from RNA polymerase II promoter • negative regulation of I-kappaB kinase/NF-kappaB signaling • transcription, DNA-templated • negative regulation of JNK cascade • cell cycle • cell proliferation • viral process • regulation of transcription elongation from RNA polymerase II promoter • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10771	66505
Ensembl	ENSG00000015171	ENSMUSG00000021156
UniProt	Q15326	Q8R5C8
RefSeq (mRNA)	NM_001202464 NM_001202465 NM_001202466 NM_001202467 NM_001202468 NM_006624 NM_212479	NM_001199141 NM_144516
RefSeq (protein)	NP_001189393.1 NP_001189394.1 NP_001189396.1 NP_001189397.1 NP_006615.2 NP_997644.2	NP_001186070.1
Location (UCSC)	Chr 10: 0.13 – 0.25 Mb	Chr 13: 9.68 – 9.77 Mb
PubMed search	[1]	[2]
Wikidata

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Zinc finger MYND domain-containing protein 11 is a protein that in humans is encoded by the ZMYND11 gene.^[3][4][5]

Function

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]

Interactions

ZMYND11 has been shown to interact with:

• BMPR1A,^[6]
• C11orf30,^[7]
• ETS2,^[8] and
• MAP3K7IP1.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, Bernards R (Jul 1995). "BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation". The EMBO Journal. 14 (13): 3159–69. PMC 394377. PMID 7621829.
4. Masselink H, Bernards R (Mar 2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene. 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313.
5. "Entrez Gene: ZMYND11 zinc finger, MYND domain containing 11".
6. Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (Apr 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660.
7. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/s0092-8674(03)00930-9. PMID 14651845.
8. Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC. "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID 12894593.

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (Apr 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660.
• Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (Apr 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". The Journal of Biological Chemistry. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
• Ansieau S, Leutz A (Feb 2002). "The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif". The Journal of Biological Chemistry. 277 (7): 4906–10. doi:10.1074/jbc.M110078200. PMID 11733528.
• Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID 12894593.
• Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. PMID 14651845.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Isobe T, Uchida C, Hattori T, Kitagawa K, Oda T, Kitagawa M (Jan 2006). "Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69". Biochemical and Biophysical Research Communications. 339 (1): 367–74. doi:10.1016/j.bbrc.2005.11.028. PMID 16300738.
• Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, Chui YL, Cui Y, Tao Q, Yamamoto M, Akira S, Wu Z (Jan 2006). "BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway". Molecular and Cellular Biology. 26 (2): 448–56. doi:10.1128/MCB.26.2.448-456.2006. PMC 1346911. PMID 16382137.
• Velasco G, Grkovic S, Ansieau S (Jun 2006). "New insights into BS69 functions". The Journal of Biological Chemistry. 281 (24): 16546–50. doi:10.1074/jbc.M600573200. PMID 16565076.