(+)-T-muurolol synthase

(+)-T-muurolol synthase
Identifiers
EC number 4.2.3.98
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(+)-T-muurolol synthase (EC 4.2.3.98) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-T-muurolol-forming).[1] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H2O (+)-T-muurolol + diphosphate

The cyclization mechanism involves an intermediate nerolidyl diphosphate.

References

  1. Hu, Y.; Chou, W.K.; Hopson, R.; Cane, D.E. (2011). "Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases". Chem. Biol. 18: 32–37. doi:10.1016/j.chembiol.2010.11.008. PMID 21276937.

External links

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