(Methyl-Co(III) methanol-specific corrinoid protein):coenzyme M methyltransferase

(Methyl-Co(III) methanol-specific corrinoid protein):coenzyme M methyltransferase (EC 2.1.1.246, methyltransferase 2, mtaA (gene)) is an enzyme with systematic name methylated methanol-specific corrinoid protein:coenzyme M methyltransferase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

[methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M

\rightleftharpoons

methyl-CoM + [Co(I) methanol-specific corrinoid protein]

Free methylcob(I)alamin can substitute for the corrinoid protein in vitro.

References

↑ LeClerc, G.M.; Grahame, D.A. (1996). "Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression". J. Biol. Chem. 271: 18725–18731. doi:10.1074/jbc.271.31.18725. PMID 8702528.
↑ Harms, U.; Thauer, R.K. (1996). "Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli". Eur. J. Biochem. 235: 653–659. doi:10.1111/j.1432-1033.1996.00653.x. PMID 8654414.
↑ Sauer, K.; Thauer, R.K. (1997). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Zinc dependence and thermodynamics of the methanol:cob(I)alamin methyltransferase reaction". Eur. J. Biochem. 249: 280–285. doi:10.1111/j.1432-1033.1997.t01-1-00280.x. PMID 9363780.
↑ Sauer, K.; Harms, U.; Thauer, R.K. (1997). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Purification, properties and encoding genes of the corrinoid protein MT1". Eur. J. Biochem. 243: 670–677. doi:10.1111/j.1432-1033.1997.t01-1-00670.x. PMID 9057830.
↑ Sauer, K.; Thauer, R.K. (1999). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri – substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin". Eur. J. Biochem. 261: 674–681. doi:10.1046/j.1432-1327.1999.00355.x. PMID 10215883.

External links

(methyl-Co(III) methanol-specific corrinoid protein):coenzyme M methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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