2-Amino-4-deoxychorismate synthase

2-amino-4-deoxychorismate synthase
Identifiers
EC number	2.6.1.86
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-amino-4-deoxychorismate synthase (EC 2.6.1.86, ADIC synthase, 2-amino-2-deoxyisochorismate synthase, SgcD) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:2-oxoglutarate aminotransferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

(2S)-2-amino-4-deoxychorismate + L-glutamate $\rightleftharpoons$ chorismate + L-glutamine

This enzyme requires Mg²⁺. The reaction occurs in the reverse direction.

References

1. Van Lanen, S.G.; Lin, S.; Shen, B. (2008). "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism". Proc. Natl. Acad. Sci. USA. 105 (2): 494–499. doi:10.1073/pnas.0708750105. PMC 2206564. PMID 18182490.
2. Yu, L.; Mah, S.; Otani, T.; Dedon, P. (1995). "The benzoxazolinate of C-1027 confers intercalative DNA binding". J. Am. Chem. Soc. 117: 8877–8878. doi:10.1021/ja00139a032.
3. McDonald, M.; Mavrodi, D.V.; Thomashow, L.S.; Floss, H.G. (2001). "Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid". J. Am. Chem. Soc. 123: 9459–9460. doi:10.1021/ja011243. PMID 11562236.
4. Laursen, J.B.; Nielsen, J. (2004). "Phenazine natural products: biosynthesis, synthetic analogues, and biological activity". Chem. Rev. 104 (3): 1663–1686. doi:10.1021/cr020473j. PMID 15008629.

External links

• 2-amino-4-deoxychorismate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)