23S rRNA (cytosine1962-C5)-methyltransferase

23S rRNA (cytosine¹⁹⁶²-C⁵)-methyltransferase (EC 2.1.1.191, RlmI, rRNA large subunit methyltransferase I, YccW) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (cytosine¹⁹⁶²-C⁵)-methyltransferase.^[1]^[2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytosine¹⁹⁶² in 23S rRNA

\rightleftharpoons

S-adenosyl-L-homocysteine + 5-methylcytosine¹⁹⁶² in 23S rRNA

The enzyme specifically methylates cytosine¹⁹⁶² at C⁵ in 23S rRNA.

References

↑ Purta, E.; O'Connor, M.; Bujnicki, J.M.; Douthwaite, S. (2008). "YccW is the m⁵C methyltransferase specific for 23S rRNA nucleotide 1962". J. Mol. Biol. 383 (3): 641–651. doi:10.1016/j.jmb.2008.08.061. PMID 18786544.
↑ Sunita, S.; Tkaczuk, K.L.; Purta, E.; Kasprzak, J.M.; Douthwaite, S.; Bujnicki, J.M.; Sivaraman, J. (2008). "Crystal structure of the Escherichia coli 23S rRNA:m⁵C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes". J. Mol. Biol. 383 (3): 652–666. doi:10.1016/j.jmb.2008.08.062. PMID 18789337.

External links

23S rRNA (cytosine1962-C5)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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