2alpha-hydroxytaxane 2-O-benzoyltransferase
2-alpha-hydroxytaxane 2-O-benzoyltransferase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC number | 2.3.1.166 | ||||||||
CAS number | 329318-50-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
|
In enzymology, a 2alpha-hydroxytaxane 2-O-benzoyltransferase (EC 2.3.1.166) is an enzyme that catalyzes the chemical reaction
- benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III CoA + 10-deacetylbaccatin III
Thus, the two substrates of this enzyme are benzoyl-CoA and 10-deacetyl-2-debenzoylbaccatin III, whereas its two products are CoA and 10-deacetylbaccatin III.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase. This enzyme is also called benzoyl-CoA:taxane 2alpha-O-benzoyltransferase. This enzyme participates in diterpenoid biosynthesis.
References
- Walker K, Croteau R (2000). "Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13591–6. doi:10.1073/pnas.250491997. PMC 17620. PMID 11095755.
This article is issued from Wikipedia - version of the 8/10/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.