3'-Fluoro-3'-deoxythymidine

Not to be confused with Alovudine.

3'-Fluoro-3'-deoxythymidine
Identifiers

Synonyms	[18F]Fluorothymidine
CAS Number	25526-93-6
PubChem (CID)	33039
ChemSpider	30578
UNII	PG53R0DWDQ
KEGG	D02830
ChEMBL	CHEMBL105318
Chemical and physical data
Formula	C₁₀H₁₃F₂N₂O₄
Molar mass	244.22 g/mol
3D model (Jmol)	Interactive image
SMILES O=C/1NC(=O)N(\C=C\1C)[C@@H]2O[C@@H]([C@@H](F)C2)CO
InChI InChI=1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1 Key:UXCAQJAQSWSNPQ-XLPZGREQSA-N

¹⁸F-3'-Fluoro-3'-deoxythymidine or ¹⁸F-FLT is a tumor-specific PET tracer (radiopharmaceutical) . FLT is suitable for monitoring how tumor responds on cytostatic therapy. It accumulates in proliferating cells - it indicates the activity of ensyme thymidine kinase which characterise the activity of cell division. FLT is phosphorylated as thymidine before incorporating into DNA. Thymidine is essential for DNA replication. Considering missing 3-hydroxy group, polymerisation of DNA is stopped by incorporating of FLT. FLT indicates change of tumor cells proliferation by tracking the restoration of nucleosides from degenerated DNA.^[1]

References

↑ Wagner, M; Seitz, U; Buck, A; Neumaier, B; Schultheiss, S; Bangerter, M; Bommer, M; Leithäuser, F; Wawra, E; Munzert, G; Reske, S. N. (2003). "3'-18Ffluoro-3'-deoxythymidine (18F-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-Cell lymphoma model and in the human disease" (PDF). Cancer research. 63 (10): 2681–7. PMID 12750297.

Diagnostic agents (V04)

Digestive system

Diabetes	Glucose Tolbutamide

Fat absorption	Vitamin A concentrates

Bile duct patency	Ceruletide Magnesium sulfate Sincalide Sorbitol

Liver functional capacity	Galactose Sulfobromophthalein

Gastric secretion	Betazole Caffeine and sodium benzoate Cation exchange resins Histamine phosphate Methylthioninium chloride Pentagastrin

Exocrine pancreatic function	Bentiromide Pancreozymin cholecystokinin Secretin

Endocrine system

Pituitary function	cortisol Corticorelin Metyrapone GH Pralmorelin Sermorelin Somatorelin

Thyroid function	Protirelin Thyrotropin

Fertility disturbances	Gonadorelin

Tuberculosis

Tuberculin

Renal function

This article is issued from Wikipedia - version of the 4/2/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.