ALDH8A1

ALDH8A1
Identifiers
Aliases	ALDH8A1, aldehyde dehydrogenase 8 family, member A1, ALDH12, DJ352A20.2, aldehyde dehydrogenase 8 family member A1
External IDs	MGI: 2653900 HomoloGene: 23369 GeneCards: ALDH8A1
Gene ontology Molecular function • oxidoreductase activity • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor • aldehyde dehydrogenase (NAD) activity • retinal dehydrogenase activity Cellular component • cytoplasm • cytosol • extracellular exosome • intracellular Biological process • metabolic process • 9-cis-retinoic acid biosynthetic process • oxidation-reduction process • retinoic acid metabolic process • retinal metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64577	237320
Ensembl	ENSG00000118514	ENSMUSG00000037542
UniProt	Q9H2A2	Q8BH00
RefSeq (mRNA)	NM_001193480 NM_022568 NM_170771	NM_178713
RefSeq (protein)	NP_001180409.1 NP_072090.1 NP_739577.1	NP_848828.1
Location (UCSC)	Chr 6: 134.92 – 134.95 Mb	Chr 10: 21.38 – 21.4 Mb
PubMed search	[1]	[2]
Wikidata

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Aldehyde dehydrogenase 8 family, member A1 also known as ALDH8A1 is an enzyme that in humans is encoded by the ALDH8A1 gene.^[3]

Function

This protein belongs to the aldehyde dehydrogenase family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Two transcript variants encoding distinct isoforms have been identified for this gene.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Lin M, Napoli JL (December 2000). "cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12". The Journal of Biological Chemistry. 275 (51): 40106–12. doi:10.1074/jbc.M008027200. PMID 11007799.
4. "Entrez Gene: ALDH8A1".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.