Alpha-farnesene synthase

Alpha-farnesene synthase (EC 4.2.3.46, (E,E)-alpha-farnesene synthase, AFS1, MdAFS1) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate lyase ((3E,6E)-alpha-farnesene-forming).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate

\rightleftharpoons

(3E,6E)-alpha-farnesene + diphosphate

References

↑ Pechous, S.W.; Whitaker, B.D. (2004). "Cloning and functional expression of an (E,E)-α-farnesene synthase cDNA from peel tissue of apple fruit". Planta. 219 (1): 84–94. doi:10.1007/s00425-003-1191-4. PMID 14740213.
↑ Green, S.; Squire, C.J.; Nieuwenhuizen, N.J.; Baker, E.N.; Laing, W. (2009). "Defining the potassium binding region in an apple terpene synthase". J. Biol. Chem. 284 (13): 8661–8669. doi:10.1074/jbc.m807140200. PMID 19181671.
↑ Nieuwenhuizen, N.J.; Wang, M.Y.; Matich, A.J.; Green, S.A.; Chen, X.; Yauk, Y.K.; Beuning, L.L.; Nagegowda, D.A.; Dudareva, N.; Atkinson, R.G. (2009). "Two terpene synthases are responsible for the major sesquiterpenes emitted from the flowers of kiwifruit (Actinidia deliciosa)". J. Exp. Bot. 60 (11): 3203–3219. doi:10.1093/jxb/erp162. PMID 19516075.

External links

Alpha-farnesene synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase

4.2.2: Acting on polysaccharides	Hyaluronate lyase

4.2.3: Acting on phosphates	Threonine synthase

4.2.99: Other	Carboxymethyloxysuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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