Arsenite methyltransferase
For the human enzyme, see AS3MT.
| Arsenite methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.137 | ||||||||
| CAS number | 167140-41-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Arsenite methyltransferase (EC 2.1.1.137, S-adenosyl-L-methionine:arsenic(III) methyltransferase, S-adenosyl-L-methionine:methylarsonite As-methyltransferase, methylarsonite methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:arsenite As-methyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) S-adenosyl-L-methionine + arsenite S-adenosyl-L-homocysteine + methylarsonate
- (2) S-adenosyl-L-methionine + methylarsonite S-adenosyl-L-homocysteine + dimethylarsinate
An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate.
References
- ↑ Zakharyan, R.A.; Aposhian, H.V. (1999). "Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase". Chem. Res. Toxicol. 12 (12): 1278–1283. doi:10.1021/tx9901231. PMID 10604879.
- ↑ Zakharyan, R.A.; Ayala-Fierro, F.; Cullen, W.R.; Carter, D.M.; Aposhian, H.V. (1999). "Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes". Toxicol. Appl. Pharmacol. 158 (1): 9–15. doi:10.1006/taap.1999.8687. PMID 10387927.
- ↑ Zakharyan, R.A.; Wildfang, E.; Aposhian, H.V. (1996). "Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic". Toxicol. Appl. Pharmacol. 140 (1): 77–84. doi:10.1006/taap.1996.0199. PMID 8806872.
- ↑ Zakharyan, R.A.; Wu, Y.; Bogdan, G.M.; Aposhian, H.V. (1995). "Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver". Chem. Res. Toxicol. 8 (8): 1029–1038. doi:10.1021/tx00050a006. PMID 8605285.
- ↑ Lin, S.; Shi, Q.; Nix, F.B.; Styblo, M.; Beck, M.A.; Herbin-Davis, K.M.; Hall, L.L.; Simeonsson, J.B.; Thomas, D.J. (2002). "A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol". J. Biol. Chem. 277 (13): 10795–10803. doi:10.1074/jbc.M110246200. PMID 11790780.
External links
- Arsenite methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 5/16/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.