BMS-955176
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| Formula | C42H62N2O4S |
| Molar mass | 691.03 g·mol−1 |
BMS-955176 is an experimental second generation HIV maturation inhibitor under development by Bristol-Myers Squibb for use in the treatment of HIV infection. By blocking the maturation of the virus, it prevents viral reproduction in host CD4+ T cells.[1] Because it targets a different step of the viral lifecycle than medications that are currently FDA approved, it offers promise for individuals with virus that has become highly resistant to other classes of HIV drugs.[2] First generation maturation inhibitors such as bevirimat were ineffective against some naturally occurring changes (polymorphisms) in the Gag protease polyprotein; BMS-955176 has been selected to better tolerate gag polymorphisms.[3][4]
Studies
Results of a phase 2a trial of BMS-955176 was reported at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI).[5] Investigators concluded that the drug was well tolerated and effective against HIV, including strains with gag polymorphisms.[5][6] Phase 2b studies are currently ongoing in early 2016.[7][8]
References
- ↑ BMS Maturation Inhibitor Is Potent Against HIV in Early Trial
- ↑ Second-Generation Investigational HIV-1 Maturation Inhibitor Demonstrates Positive New Phase IIa Results, Supporting Continued Development
- ↑ New HIV maturation inhibitor BMS-955176 appears more potent than earlier beviramat
- ↑ Wang, Dan; Lu, Wuxun; Li, Feng (2015-11-01). "Pharmacological intervention of HIV-1 maturation". Acta Pharmaceutica Sinica B. 5 (6): 493–499. doi:10.1016/j.apsb.2015.05.004. PMC 4675807
. PMID 26713265. - 1 2 "Antiviral Activity/Safety of a Second-Generation HIV-1 Maturation Inhibitor | CROI Conference". www.croiconference.org. Retrieved 2016-01-01.
- ↑ "HIV maturation inhibitor BMS-955176 looks promising in early study". www.aidsmap.com. Retrieved 2016-01-01.
- ↑ "Dose-finding Study of BMS-955176 to Treat HIV-1 Infected Treatment-naive Adults - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2016-01-01.
- ↑ "Strategy-confirming Study of BMS-955176 to Treat HIV-1 Infected Treatment-experienced Adults - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2016-01-01.