Beta-amyrin 11-oxidase
Beta-amyrin 11-oxidase | |||||||||
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Identifiers | |||||||||
EC number | 1.14.13.134 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Beta-amyrin 11-oxidase (EC 1.14.13.134, CYP88D6) is an enzyme with systematic name beta-amyrin,NADPH:oxygen oxidoreductase (hydroxylating).[1] This enzyme catalyses the following chemical reaction
- beta-amyrin + 2 O2 + 2 NADPH + 2 H+ 11-oxo-beta-amyrin + 3 H2O + 2 NADP+ (overall reaction)
- (1a) beta-amyrin + O2 + NADPH + H+ 11alpha-hydroxy-beta-amyrin + H2O + NADP+
- (1b) 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ 11-oxo-beta-amyrin + 2 H2O + NADP+
Beta-amyrin 11-oxidase requires cytochrome P450.
References
- ↑ Seki, H.; Ohyama, K.; Sawai, S.; Mizutani, M.; Ohnishi, T.; Sudo, H.; Akashi, T.; Aoki, T.; Saito, K.; Muranaka, T. (2008). "Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin". Proc. Natl. Acad. Sci. USA. 105 (37): 14204–14209. doi:10.1073/pnas.0803876105. PMC 2532699. PMID 18779566.
External links
- Beta-amyrin 11-oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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