Nodavirus endopeptidase

Identifiers

Databases

PDB structures

Nodavirus endopeptidase (EC 3.4.23.44, Black Beetle virus endopeptidase, Flock House virus endopeptidase) is an enzyme.^[1]^[2] This enzyme catalyses the following chemical reaction

Hydrolysis of an asparaginyl bond involved in the maturation of the structural protein of the virus, typically -Asn-Ala- or -Asn-Phe-

The enzyme is coded by several nodaviruses that are insect pathogens.

References

↑ Zlotnick, A.; Reddy, V.S.; Dasgupta, R.; Schneemann, A. (1994). ", Ray,W.J., Jr., Rueckert, R.R. and Johnson, J.E. Capsid assembly in a family of animal viruses primes an autoproteolytic maturation that depends on a single aspartic acid residue". J. Biol. Chem. 269: 13680–13684. PMID 8175803.
↑ Johnson, J.E.; Schneemann, A. (1998). "Nodavirus endopeptidase". In Barrett, A.J.; Rawlings, N.D.; Woessner, J.F. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 964–967.

Proteases: aspartate proteases (EC 3.4.23)

Vertebrate	Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2

Pathogenic	Plasmepsin HIV-1 protease

Plant	Nepenthesin

Cathepsin	D E

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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