CEP55

CEP55
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3E1R, 3WUT, 3WUU, 3WUV
Identifiers
Aliases	CEP55, C10orf3, CT111, URCC6, centrosomal protein 55
External IDs	MGI: 1921357 HomoloGene: 10019 GeneCards: CEP55
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • microtubule organizing center • centriole • centrosome • cleavage furrow • cytoskeleton • membrane • intercellular bridge • midbody Biological process • cell division • cell cycle • cell separation after cytokinesis • mitotic cytokinesis • mitotic metaphase plate congression • mitotic nuclear division • nucleus organization • establishment of protein localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55165	74107
Ensembl	ENSG00000138180	ENSMUSG00000024989
UniProt	Q53EZ4	Q8BT07
RefSeq (mRNA)	NM_001127182 NM_018131	NM_001164362 NM_028293 NM_028760
RefSeq (protein)	NP_001120654.1 NP_060601.3	NP_001157834.1 NP_082569.1 NP_083036.2
Location (UCSC)	Chr 10: 93.5 – 93.53 Mb	Chr 19: 38.06 – 38.07 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Centrosomal protein of 55 kDa is a protein that in humans is encoded by the CEP55 gene.^[3][4]

CEP55 is a mitotic phosphoprotein that plays a key role in cytokinesis, the final stage of cell division.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Fabbro M, Zhou BB, Takahashi M, Sarcevic B, Lal P, Graham ME, Gabrielli BG, Robinson PJ, Nigg EA, Ono Y, Khanna KK (Oct 2005). "Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis". Dev Cell. 9 (4): 477–88. doi:10.1016/j.devcel.2005.09.003. PMID 16198290.
4. "Entrez Gene: CEP55 centrosomal protein 55kDa".
5. van der Horst A, Simmons J, Khanna KK (November 2009). "Cep55 stabilization is required for normal execution of cytokinesis". Cell Cycle. 8 (22): 3742–9. doi:10.4161/cc.8.22.10047. PMID 19855176.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Martinez-Garay I, Rustom A, Gerdes HH, Kutsche K (2006). "The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody". Genomics. 87 (2): 243–53. doi:10.1016/j.ygeno.2005.11.006. PMID 16406728.
• Zhao WM, Seki A, Fang G (2006). "Cep55, a Microtubule-bundling Protein, Associates with Centralspindlin to Control the Midbody Integrity and Cell Abscission during Cytokinesis". Mol. Biol. Cell. 17 (9): 3881–96. doi:10.1091/mbc.E06-01-0015. PMC 1593165. PMID 16790497.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Chen CH, Lu PJ, Chen YC, et al. (2007). "FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway". Oncogene. 26 (29): 4272–83. doi:10.1038/sj.onc.1210207. PMID 17237822.
• Carlton JG, Martin-Serrano J (2007). "Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery". Science. 316 (5833): 1908–12. doi:10.1126/science.1143422. PMID 17556548.
• Morita E, Sandrin V, Chung HY, et al. (2007). "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis". EMBO J. 26 (19): 4215–27. doi:10.1038/sj.emboj.7601850. PMC 2230844. PMID 17853893.