Carboxypeptidase U
| Carboxypeptidase U | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.17.20 | ||||||||
| CAS number | 156621-18-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Carboxypeptidase U (EC 3.4.17.20, arginine carboxypeptidase, carboxypeptidase R, plasma carboxypeptidase B, thrombin-activatable fibrinolysis inhibitor) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Release of C-terminal Arg and Lys from a polypeptide
Pro-carboxypeptidase U in (human) plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
See also
References
- ↑ Eaton, D.L.; Malloy, B.E.; Tsai, S.P.; Henzel, W.; Drayna, D. (1991). "Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma". J. Biol. Chem. 266: 21833–21838. PMID 1939207.
- ↑ Shinohara, T.; Sakurada, C.; Suzuki, T.; Takeuchi, O.; Campbell, W.; Ikeda, S.; Okada, N.; Okada, H. (1994). "Pro-carboxypeptidase R cleaves bradykinin following activation". Int. Arch. Allergy Immunol. 103: 400–404. doi:10.1159/000236661. PMID 8130654.
- ↑ Wang, W.; Hendriks, D.F.; Scharpé, S. (1994). "Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen". J. Biol. Chem. 269: 15937–15944. PMID 8195249.
- ↑ Tan, A.K.; Eaton, D.L. (1995). "Activation and characterization of procarboxypeptidase B from human plasma". Biochemistry. 34: 5811–5816. doi:10.1021/bi00017a012. PMID 7727441.
- ↑ Broze, G.J.; Jr.; Higuchi, D.A. (1996). "Coagulation-dependent inhibition of fibrinolysis: Role of carboxypeptidase U and the premature lysis of clots from hemophilic plasma". Blood. 88: 3815–3823. PMID 8916945.
External links
- Carboxypeptidase U at the US National Library of Medicine Medical Subject Headings (MeSH)
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