DATP(dGTP)—DNA purinetransferase
| DATP(dGTP)---DNA purinetransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.6.99.1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
DATP(dGTP)---DNA purinetransferase (EC 2.6.99.1) is an enzyme with systematic name dATP(dGTP):depurinated-DNA purine transferase.[1][2] This enzyme catalyses the following chemical reaction
- (1) dATP + depurinated DNA deoxyribose triphosphate + DNA
- (2) dGTP + depurinated DNA deoxyribose triphosphate + DNA
The purine residue is transferred on to the apurinic site forming a normal glycosylic bond.
References
- ↑ Deutsch, W.A.; Linn, S. (1979). "DNA binding activity from cultured human fibroblasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites". Proc. Natl. Acad. Sci. USA. 76: 141–144. doi:10.1073/pnas.76.1.141. PMID 218192.
- ↑ Livneh, Z.; Elad, D.; Sperling, J. (1979). "Enzymatic insertion of purine bases into depurinated DNA in vitro". Proc. Natl. Acad. Sci. USA. 76: 1089–1093. doi:10.1073/pnas.76.3.1089. PMID 375225.
External links
- DATP(dGTP)---DNA purinetransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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