Demethylmenaquinone methyltransferase

Demethylmenaquinone methyltransferase (EC 2.1.1.163, S-adenosyl-L-methione-DMK methyltransferase, demethylmenaquinone C-methylase, 2-heptaprenyl-1,4-naphthoquinone methyltransferase, 2-demethylmenaquinone methyltransferase, S-adenosyl-L-methione:2-demethylmenaquinone methyltransferase) is an enzyme with systematic name S-adenosyl-L-methione:demethylmenaquinone methyltransferase.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

demethylmenaquinol + S-adenosyl-L-methionine

\rightleftharpoons

menaquinol + S-adenosyl-L-homocysteine

The enzyme catalyses the last step in menaquinone biosynthesis.

References

↑ Koike-Takeshita, A.; Koyama, T.; Ogura, K. (1997). "Identification of a novel gene cluster participating in menaquinone (vitamin K₂) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus". J. Biol. Chem. 272 (19): 12380–12383. doi:10.1074/jbc.272.19.12380. PMID 9139683.
↑ Wissenbach, U.; Ternes, D.; Unden, G. (1992). "An Escherichia coli mutant containing only demethylmenaquinone, but no menaquinone: effects on fumarate, dimethylsulfoxide, trimethylamine N-oxide and nitrate respiration". Arch. Microbiol. 158 (1): 68–73. doi:10.1007/BF00249068. PMID 1444716.
↑ Catala, F.; Azerad, R.; Lederer, E. (1970). "Sur les propriétés de la desméthylménaquinone C-méthylase de Mycobacterium phlei". Int. Z. Vitaminforsch. 40 (3): 363–373. PMID 5450997.
↑ Lee, P.T.; Hsu, A.Y.; Ha, H.T.; Clarke, C.F. (1997). "A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene". J. Bacteriol. 179 (5): 1748–1754. PMC 178890. PMID 9045837.

External links

Demethylmenaquinone methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-

N-	Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase

O-	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase Catechol-O-methyl transferase

Homocysteine	Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase

Other	Phosphatidyl ethanolamine methyltransferase DNMT3B Histone methyltransferase Thymidylate synthase DNA methyltransferase Thiopurine methyltransferase

2.1.2: Hydroxymethyl-,
Formyl- and Related

Hydroxymethyltransferase	Serine hydroxymethyltransferase 3-methyl-2-oxobutanoate hydroxymethyltransferase

Formyltransferase	Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase

Other	Glutamate formimidoyltransferase Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl

Carboxy	methylmalonyl-CoA carboxytransferase

Carbamoyl	Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase

2.1.4: Amidine

Arginine:glycine amidinotransferase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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