Farnesyltranstransferase

farnesyltranstransferase
Identifiers
EC number 2.5.1.29
CAS number 9032-58-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a farnesyltranstransferase (EC 2.5.1.29) is an enzyme that catalyzes the chemical reaction

trans,trans-farnesyl diphosphate + isopentenyl diphosphate diphosphate + geranylgeranyl diphosphate

Thus, the two substrates of this enzyme are trans,trans-farnesyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and geranylgeranyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase. Other names in common use include geranylgeranyl-diphosphate synthase, geranylgeranyl pyrophosphate synthetase, geranylgeranyl-PP synthetase, farnesyltransferase, and geranylgeranyl pyrophosphate synthase. This enzyme participates in biosynthesis of steroids and terpenoid biosynthesis.

This protein may use the morpheein model of allosteric regulation.[1]

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2DH4 and 2Q80.

References

  1. T. Selwood; E. K. Jaffe. (2011). "Dynamic dissociating homo-oligomers and the control of protein function.". Arch. Biochem. Biophys. 519 (2): 131–43. doi:10.1016/j.abb.2011.11.020. PMC 3298769Freely accessible. PMID 22182754.


This article is issued from Wikipedia - version of the 8/10/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.