Fasoracetam

Fasoracetam

Names
IUPAC name (5R)-5-(piperidine-1-carbonyl) pyrrolidin-2-one
Other names (5R)-5-oxo-D-prolinepiperidinamide
Identifiers
CAS Number	110958-19-5
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL2106179
ChemSpider	171980
KEGG	C13311
PubChem	198695
InChI InChI=1S/C10H16N2O2/c13-9-5-4-8(11-9)10(14)12-6-2-1-3-7-12/h8H,1-7H2,(H,11,13)/t8-/m1/s1 Key: GOWRRBABHQUJMX-MRVPVSSYSA-N InChI=1/C10H16N2O2/c13-9-5-4-8(11-9)10(14)12-6-2-1-3-7-12/h8H,1-7H2,(H,11,13)/t8-/m1/s1 Key: GOWRRBABHQUJMX-MRVPVSSYBL
SMILES O=C(N1CCCCC1)[C@@H]2NC(=O)CC2
Properties
Chemical formula	C10H16N2O2
Molar mass	196.25 g·mol^−1
Pharmacology
Routes of administration	Oral
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Fasoracetam (NS-105, 5-oxo-D-prolinepiperidinamide monohydrate)^[1] is a research chemical of the racetam family.^[2] It is a nootropic, and has been in a clinical trial for attention deficit hyperactivity disorder.^[3]

In in vitro studies on mouse neurons, fasoracetam modulated mGluR II/III activity.^[4] In studies in rats, it blocked memory disruptions caused by baclofen, a GABA_B agonist^[5] and upregulated production of GABA_B receptors after repeat dosing.^[6]

References

1. FDA/NIH Substance registration system. Page accessed March 21, 2016
2. "5-oxo-D-prolinepiperidinamide monohydrate - Compound Summary". Retrieved 21 July 2013.
3. "Drug Profile Fasoracetam".
4. "A novel cognition enhancer NS-105 modulates adenylate cyclase activity through metabotropic glutamate receptors in primary neuronal culture."..
5. "Involvement of cholinergic and GABAergic systems in the reversal of memory disruption by NS-105, a cognition enhancer.".
6. "Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment.".