Galactoside O-acetyltransferase

Galactoside O-acetyltransferase
Identifiers
EC number 2.3.1.18
CAS number 9029-94-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
Thiogalactoside acetyltransferase
Identifiers
Organism Escherichia coli
Symbol lacA
Entrez 945674
RefSeq (Prot) NP_414876
UniProt P07464

Galactoside O-acetyltransferase (also known as thiogalactoside transacetylase) is an enzyme encoded by the lacA gene in E. coli. The protein plays a role in cell detoxification.[1]

Reaction

It catalyzes the following reaction:

acetyl-CoA + beta-D-galactosideCoA + 6-acetyl-beta-D-galactoside

Structure

In E. coli, thiogalactoside transacetylase is a dimer. Its monomer consists of 202 amino acid residues. The protein has a molecular weight of 22,671.[2]

The amino terminus of the protein is heterogenous because the initiator methionine is only partially cleaved. The protein is found in the cell cytoplasm and contains a highly hydrophobic segment in its center.

See also

References

  1. "Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification.". 1976.
  2. "The amino acid sequence of thiogalactoside transacetylase of Escherichia coli.". Biochimie. 67 (1): 101–8. 1985. doi:10.1016/s0300-9084(85)80235-2. PMID 3922433.
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