HOOK1

HOOK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WIX
Identifiers
Aliases	HOOK1, HK1, hook microtubule-tethering protein 1
External IDs	MGI: 1925213 HomoloGene: 9289 GeneCards: HOOK1
Gene ontology Molecular function • microtubule binding • actin binding • protein binding • identical protein binding Cellular component • HOPS complex • cytoplasm • microtubule cytoskeleton • microtubule • cytoskeleton • FHF complex • cytosol Biological process • multicellular organism development • protein transport • transport • cell differentiation • lysosome organization • early endosome to late endosome transport • spermatogenesis • endosome organization • spermatid development • endosome to lysosome transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51361	77963
Ensembl	ENSG00000134709	ENSMUSG00000028572
UniProt	Q9UJC3	Q8BIL5
RefSeq (mRNA)	NM_015888	NM_030014
RefSeq (protein)	NP_056972.1	NP_084290.1
Location (UCSC)	Chr 1: 59.81 – 59.88 Mb	Chr 4: 95.97 – 96.03 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Protein Hook homolog 1 is a protein that in humans is encoded by the HOOK1 gene.^[3][4]

Function

This gene encodes a member of the hook family of coiled coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Kramer H, Phistry M (Mar 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. PMC 1460498. PMID 9927460.
4. "Entrez Gene: HOOK1 hook homolog 1 (Drosophila)".

Further reading

• Walenta JH, Didier AJ, Liu X, Krämer H (2001). "The Golgi-Associated Hook3 Protein Is a Member of a Novel Family of Microtubule-Binding Proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.
• Mendoza-Lujambio I, Burfeind P, Dixkens C, et al. (2003). "The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse". Hum. Mol. Genet. 11 (14): 1647–58. doi:10.1093/hmg/11.14.1647. PMID 12075009.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Luiro K, Yliannala K, Ahtiainen L, et al. (2005). "Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway". Hum. Mol. Genet. 13 (23): 3017–27. doi:10.1093/hmg/ddh321. PMID 15471887.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Weimer JM, Chattopadhyay S, Custer AW, Pearce DA (2005). "Elevation of Hook1 in a disease model of Batten disease does not affect a novel interaction between Ankyrin G and Hook1". Biochem. Biophys. Res. Commun. 330 (4): 1176–81. doi:10.1016/j.bbrc.2005.03.103. PMID 15823567.
• Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.