Homospermidine synthase (spermidine-specific)

homospermidine synthase (spermidine-specific)
Identifiers
EC number	2.5.1.45
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a homospermidine synthase (spermidine-specific) (EC 2.5.1.45) is an enzyme that catalyzes the chemical reaction

spermidine + putrescine $\rightleftharpoons$ sym-homospermidine + propane-1,3-diamine

Thus, the two substrates of this enzyme are spermidine and putrescine, whereas its two products are sym-homospermidine and propane-1,3-diamine.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming).

References

• Ostrovsky AN, Grischenko AV, Taylor PD, Bock P, Mawatari SF (2006). "Comparative anatomical study of internal brooding in three anascan bryozoans (Cheilostomata) and its taxonomic and evolutionary implications". J. Morphol. 267 (6): 739–49. doi:10.1002/jmor.10438. PMID 16526057.
• Ober D, Hartmann T (1999). "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 14777–82. doi:10.1073/pnas.96.26.14777. PMC 24724. PMID 10611289.
• Ober D, Harms R, Hartmann T (2000). "Cloning and expression of homospermidine synthase from Senecio vulgaris: a revision". Phytochemistry. 55 (4): 311–316. doi:10.1016/S0031-9422(00)00267-3. PMID 11117877.