IQCB1

IQCB1
Identifiers
Aliases	IQCB1, NPHP5, PIQ, SLSN5, IQ motif containing B1
External IDs	MGI: 2443764 HomoloGene: 8766 GeneCards: IQCB1
Gene ontology Molecular function • enzyme binding • protein binding • calmodulin binding Cellular component • intercellular bridge • microtubule cytoskeleton • cytoplasm • microtubule organizing center • cytosol • centrosome • photoreceptor outer segment • extracellular exosome • cytoskeleton • nucleoplasm • photoreceptor connecting cilium • centriole Biological process • cilium assembly • photoreceptor cell maintenance • maintenance of animal organ identity • cell projection organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9657	320299
Ensembl	ENSG00000173226	ENSMUSG00000022837
UniProt	Q15051	Q8BP00
RefSeq (mRNA)	NM_001023570 NM_001023571 NM_001319107	NM_177128
RefSeq (protein)	NP_001018864.2 NP_001018865.2 NP_001306036.1	NP_796102.2
Location (UCSC)	Chr 3: 121.77 – 121.84 Mb	Chr 16: 36.83 – 36.87 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

IQ calmodulin-binding motif-containing protein 1 is a protein that in humans is encoded by the IQCB1 gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Otto EA, Loeys B, Khanna H, Hellemans J, Sudbrak R, Fan S, Muerb U, O'Toole JF, Helou J, Attanasio M, Utsch B, Sayer JA, Lillo C, Jimeno D, Coucke P, De Paepe A, Reinhardt R, Klages S, Tsuda M, Kawakami I, Kusakabe T, Omran H, Imm A, Tippens M, Raymond PA, Hill J, Beales P, He S, Kispert A, Margolis B, Williams DS, Swaroop A, Hildebrandt F (Feb 2005). "Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin". Nat Genet. 37 (3): 282–8. doi:10.1038/ng1520. PMID 15723066.
4. "Entrez Gene: IQCB1 IQ motif containing B1".

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Mollet G, Salomon R, Gribouval O, et al. (2002). "The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin.". Nat. Genet. 32 (2): 300–5. doi:10.1038/ng996. PMID 12244321.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mollet G, Silbermann F, Delous M, et al. (2005). "Characterization of the nephrocystin/nephrocystin-4 complex and subcellular localization of nephrocystin-4 to primary cilia and centrosomes.". Hum. Mol. Genet. 14 (5): 645–56. doi:10.1093/hmg/ddi061. PMID 15661758.
• le Maire A, Weber T, Saunier S, et al. (2006). "Solution NMR structure of the SH3 domain of human nephrocystin and analysis of a mutation-causing juvenile nephronophthisis.". Proteins. 59 (2): 347–55. doi:10.1002/prot.20344. PMID 15723349.
• Luo X, He Q, Huang Y, Sheikh MS (2006). "Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers.". Cancer Res. 65 (23): 10725–33. doi:10.1158/0008-5472.CAN-05-1132. PMID 16322217.