IGK@

IGK
Identifiers
Aliases	IGK, IGK@, immunoglobulin kappa locus
External IDs	GeneCards: IGK
Orthologs
Species	Human	Mouse
Entrez	50802	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins).^[2]

In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region.^[3] These genes undergo V(D)J recombination to generate a diverse repertoire of immunoglobulins.

Genes

The immunoglobulin kappa locus contains the following genes:

• IGKC: immunoglobulin kappa constant
• IGKJ@: immunoglobulin kappa joining group
  • IGKJ1, IGKJ2, IGKJ3, IGKJ4, IGKJ5
• IGKV@: immunoglobulin kappa variable group
  • IGKV1-5, IGKV1-6, IGKV1-8, IGKV1-9, IGKV1-12, IGKV1-16, IGKV1-17, IGKV1-27, IGKV1-33
  • IGKV1D-8, IGKV1D-12, IGKV1D-13, IGKV1D-16, IGKV1D-17, IGKV1D-22, IGKV1D-27, IGKV1D-32, IGKV1D-33, IGKV1D-39, IGKV1D-43
  • IGKV2-24, IGKV2-28, IGKV2-30, IGKV2-40
  • IGKV2D-26, IGKV2D-28, IGKV2D-29, IGKV2D-30, IGKV2D-40
  • IGKV3-11, IGKV3-15, IGKV3-20
  • IGKV3D-7, IGKV3D-11, IGKV3D-20
  • IGKV4-1
  • IGKV5-2
• and a number of non-functional and pseudogenes

References

1. "Human PubMed Reference:".
2. Criscitiello MF, Flajnik MF (2007). "Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates". Eur. J. Immunol. 37 (10): 2683–94. doi:10.1002/eji.200737263. PMID 17899545.
3. Male, D., Brostoff, J., Roth, D.B., & Roitt, I. 2006. Immunology. 7th ed., Canada: Elsevier Limited

Further reading