Initiator element

The initiator element (Inr), sometimes also called initiator motif, is a core promoter that is similar in function to the Pribnow box (for prokaryotes) or the TATA box (for eukaryotes). It has the consensus sequence YYANWYY.[lower-alpha 1][1] Similarly to the TATA box, the Inr element facilitates the binding of transcription Factor II D (TAF).[1] TATA box and Inr are usually mutually exclusive.

Notes

  1. ↑ In nucleic acid notation for DNA, Y (pYrimidine) stands for C/T (cytosine or thymine, which are both pyrimidines), N (Nucleobase) is any of the four bases, and W (Weak) stands for A/T (adenine or thymine, which both form only two hydrogen bonds)

References

  1. 1 2 Xi, Hualin; Yong Yu; Yutao Fu; Jonathan Foley; Anason Halees; Zhiping Weng (June 2007). "Analysis of overrepresented motifs in human core promoters reveals dual regulatory roles of YY1". Genome Research. 17 (6): 798–806. doi:10.1101/gr.5754707. PMC 1891339Freely accessible. PMID 17567998.
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