Interleukin 34

IL34
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DKC, 4DKD, 4DKE, 4DKF
Identifiers
Aliases	IL34, C16orf77, IL-34, Interleukin 34
External IDs	MGI: 1923777 HomoloGene: 12648 GeneCards: IL34
Gene ontology Molecular function • macrophage colony-stimulating factor receptor binding • cytokine activity • growth factor activity Cellular component • extracellular space • extracellular region Biological process • positive regulation of monocyte differentiation • positive regulation of macrophage differentiation • positive regulation of protein phosphorylation • innate immune response • inflammatory response • positive regulation of cell proliferation • immune system process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	146433	76527
Ensembl	ENSG00000157368	ENSMUSG00000031750
UniProt	Q6ZMJ4	Q8R1R4
RefSeq (mRNA)	NM_001172771 NM_001172772 NM_152456	NM_001135100 NM_029646
RefSeq (protein)	NP_001166242.1 NP_001166243.1 NP_689669.2	NP_001128572.1 NP_083922.1
Location (UCSC)	Chr 16: 70.58 – 70.66 Mb	Chr 8: 110.74 – 110.81 Mb
PubMed search	[1]	[2]
Wikidata

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Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening of secreted proteins; chimpanzee, murine, rat and chicken interleukin 34 orthologs have also been found. The protein is composed of 241 amino acids, 39 kilodaltons in mass, and forms homodimers. IL-34 increases growth or survival of immune cells known as monocytes; it elicits its activity by binding the Colony stimulating factor 1 receptor.

Messenger RNA (mRNA) expression of human IL-34 is most abundant in spleen but occurs in several other tissues: thymus, liver, small intestine, colon, prostate gland, lung, heart, brain, kidney, testes, and ovary. The discovery of IL-34 protein in the red pulp of the spleen suggests involvement in growth and development of myeloid cells, consistent with its activity on monocytes. ^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Lin H, Lee E, Hestir K, et al. (May 2008). "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome". Science. 320 (5877): 807–11. doi:10.1126/science.1154370. PMID 18467591.

External links

Interleukin-34 at the US National Library of Medicine Medical Subject Headings (MeSH)