L-tryptophan—pyruvate aminotransferase
| L-tryptophan---pyruvate aminotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.6.1.99 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
L-tryptophan---pyruvate aminotransferase (EC 2.6.1.99, TAA1 (gene), vt2 (gene)) is an enzyme with systematic name L-tryptophan:pyruvate aminotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- L-tryptophan + pyruvate indole-3-pyruvate + L-alanine
This plant enzyme, along with EC 1.14.13.168, indole-3-pyruvate monooxygenase, is responsible for the biosynthesis of the plant hormone indole-3-acetate from L-tryptophan.
References
- ↑ Tao, Y.; Ferrer, J.L.; Ljung, K.; Pojer, F.; Hong, F.; Long, J.A.; Li, L.; Moreno, J.E.; Bowman, M.E.; Ivans, L.J.; Cheng, Y.; Lim, J.; Zhao, Y.; Ballare, C.L.; Sandberg, G.; Noel, J.P.; Chory, J. (2008). "Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants". Cell. 133: 164–176. doi:10.1016/j.cell.2008.01.049. PMC 2442466
. PMID 18394996. - ↑ Mashiguchi, K.; Tanaka, K.; Sakai, T.; Sugawara, S.; Kawaide, H.; Natsume, M.; Hanada, A.; Yaeno, T.; Shirasu, K.; Yao, H.; McSteen, P.; Zhao, Y.; Hayashi, K.; Kamiya, Y.; Kasahara, H. (2011). "The main auxin biosynthesis pathway in Arabidopsis". Proc. Natl. Acad. Sci. USA. 108: 18512–18517. doi:10.1073/pnas.1108434108. PMC 3215075. PMID 22025724.
- ↑ Phillips, K.A.; Skirpan, A.L.; Liu, X.; Christensen, A.; Slewinski, T.L.; Hudson, C.; Barazesh, S.; Cohen, J.D.; Malcomber, S.; McSteen, P. (2011). "vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize". Plant Cell. 23: 550–566. doi:10.1105/tpc.110.075267. PMID 21335375.
- ↑ Zhao, Y. (2012). "Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants". Mol. Plant. 5: 334–338. doi:10.1093/mp/ssr104. PMC 3309920. PMID 22155950.
External links
- L-tryptophan---pyruvate aminotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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