| Name | Nationality | Region | Appearances | Goals | Clubs (games) |
| Raúl |  Spain |  Madrid | 550 | 228 | Real Madrid |
| Iker Casillas | Spain | Madrid | 476 | 0 | Real Madrid |
| Joseba Etxeberria | Spain |  Basque Country | 452 | 90 | Real Sociedad (7), Athletic Bilbao (445) |
| Pedro Munitis | Spain |  Cantabria | 447 | 43 | Real Madrid (53), Deportivo La Coruña (90), Racing Santander (304) |
| Xavi | Spain |  Catalunya | 444 | 53 | Barcelona |
| Sergio | Spain | Catalunya | 419 | 34 | Espanyol (110), Deportivo La Coruña (295), Levante (14) |
| Raúl Tamudo | Spain | Catalunya | 407 | 146 | Espanyol (342), Real Sociedad (31), Rayo Vallecano (36) |
| Joan Capdevila | Spain | Catalunya | 405 | 35 | Espanyol (55), Atlético Madrid (31), Deportivo La Coruña (179), Villarreal (140) |
| César | Spain | .svg.png) Extremadura | 400 | 0 | Real Valladolid (205), Real Madrid (20), Real Zaragoza (110), Valencia (63), Villarreal (2) |
| Joaquín | Spain |  Andalusia | 394 | 53 | Real Betis (180), Valencia (158), Málaga (56) |
| Francisco Puñal | Spain |  Navarra | 394 | 21 | Osasuna |
| Juan Carlos Valerón | Spain |  Canarias | 390 | 30 | Mallorca (36), Atlético Madrid (65), Deportivo La Coruña (289) |
| Guti | Spain | Madrid | 387 | 46 | Real Madrid |
| Carles Puyol | Spain | Catalunya | 387 | 11 | Barcelona |
| Sergio Ballesteros | Spain | .svg.png) Valencia | 387 | 8 | Tenerife (69), Rayo Vallecano (36), Villarreal (81), Mallorca (103), Levante (88) |
| David Albelda | Spain | Valencia | 386 | 9 | Villarreal (35), Valencia (351) |
| Alberto Marcos | Spain | Madrid | 371 | 3 | Real Madrid (7), Real Valladolid (364) |
| Alberto Lopo | Spain | Catalunya | 366 | 17 | Espanyol (178), Deportivo La Coruña (151), Getafe (37) |
| Alberto | Spain | Basque Country | 351 | 0 | Real Sociedad (344), Real Valladolid (7) |
| Andoni Iraola | Spain | Basque Country | 349 | 31 | Athletic Bilbao |
| Míchel Salgado | Spain |  Galicia | 343 | 7 | Celta Vigo (92), Real Madrid (251) |
| Víctor | Spain | Extremadura | 342 | 94 | Tenerife (16), Real Valladolid (195), Villarreal (131) |
| Ariel Ibagaza |  Argentina | | 342 | 32 | Mallorca (204), Atlético Madrid (84), Villarreal (54) |
| Gonzalo Colsa | Spain | Cantabria | 340 | 29 | Real Valladolid (37), Mallorca (32), Atlético Madrid (44), Racing Santander (227) |
| Manuel Pablo | Spain | Canarias | 339 | 1 | Deportivo La Coruña |
| Rubén Baraja | Spain |  Castile and León | 338 | 48 | Real Valladolid (41), Atlético Madrid (34), Valencia (263) |
| Dani Alves |  Brazil | | 336 | 22 | Sevilla (175), Barcelona (161) |
| Fernando Morientes | Spain | Extremadura | 334 | 124 | Albacete (22), Real Zaragoza (66), Real Madrid (181), Valencia (65) |
| José Luis Martí | Spain |  Balearic Islands | 334 | 8 | Tenerife (35), Sevilla (141), Mallorca (158) |
| Carlos Marchena | Spain | Andalusia | 330 | 11 | Sevilla (33), Valencia (230), Villarreal (45), Deportivo La Coruña (22) |
| Luis García | Spain |  Asturias | 329 | 73 | Real Murcia (38), Mallorca (37), Espanyol (220), Real Zaragoza (34) |
| Leo Franco | Argentina | | 328 | 0 | Mallorca (148), Atlético Madrid (153), Real Zaragoza (27) |
| Aitor López Rekarte | Spain | Basque Country | 325 | 4 | Real Sociedad (315), Almería (10) |
| Javier Casquero | Spain | Madrid | 322 | 43 | Sevilla (106), Racing Santander (26), Getafe (190) |
| David Villa | Spain | Asturias | 316 | 176 | Real Zaragoza (73), Valencia (167), Barcelona (76) |
| Miguel Ángel Angulo | Spain | Asturias | 313 | 43 | Valencia |
| Juanfran | Spain | Valencia | 312 | 6 | Valencia (41), Celta Vigo (136), Real Zaragoza (63), Levante (82) |
| Daniel Aranzubia | Spain | Basque Country | 303 | 1 | Athletic Bilbao (163), Deportivo La Coruña (140) |
| Dudu Aouate |  Israel | | 303 | 0 | Racing Santander (78), Deportivo La Coruña (66), Mallorca (159) |
| Francisco Yeste | Spain | Basque Country | 301 | 50 | Athletic Bilbao |
| Andrés Iniesta | Spain |  Castile-La Mancha | 301 | 30 | Barcelona |
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