Lovastatin nonaketide synthase

lovastatin nonaketide synthase
Identifiers
EC number	2.3.1.161
CAS number	235426-97-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, lovastatin nonaketide synthase (EC 2.3.1.161) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 10 H⁺ + S-adenosyl-L-methionine $\rightleftharpoons$ dihydromonacolin L + 9 CoA + 8 CO₂ + 11 NADP⁺ + S-adenosyl-L-homocysteine + 6 H₂O

The 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, H⁺, and S-adenosyl-L-methionine, whereas its 6 products are dihydromonacolin L, CoA, CO₂, NADP⁺, S-adenosyl-L-homocysteine, and H₂O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing).

References

• Heever JP, Hutchinson CR, Vederas JC (2000). "Lovastatin nonaketide synthase catalyses an intramolecular Diels-Alder reaction of a substrate analogue". J. Am. Chem. Soc. 122 (46): 11519–11520. doi:10.1021/ja003216.