Methanol—5-hydroxybenzimidazolylcobamide Co-methyltransferase
| methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.90 | ||||||||
| CAS number | 86611-98-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase (EC 2.1.1.90) is an enzyme that catalyzes the chemical reaction
- methanol + 5-hydroxybenzimidazolylcobamide Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H2O
Thus, the two substrates of this enzyme are methanol and 5-hydroxybenzimidazolylcobamide, whereas its two products are Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide and H2O.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase. Other names in common use include methanol cobalamin methyltransferase, methanol:5-hydroxybenzimidazolylcobamide methyltransferase, and MT 1.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I2X.
References
- Vogels GD; Te Brömmelstroet, BW; Poirot, CM; Van Der Drift, C; Vogels, GD (1984). "Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri". J. Bacteriol. 160 (2): 629–35. PMC 214781
. PMID 6438059.