Methionine transaminase

Methionine transaminase
Identifiers
EC number 2.6.1.88
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Methionine transaminase (EC 2.6.1.88, methionine-oxo-acid transaminase) is an enzyme with systematic name L-methionine:2-oxo-acid aminotransferase.[1][2][3] This enzyme catalyses the following chemical reaction

L-methionine + 2-oxo carboxylate 2-oxo-4-methylthiobutanoate + L-amino acid

The enzyme is most active with L-methionine.

References

  1. Heilbronn, J.; Wilson, J.; Berger, B.J. (1999). "Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae". J. Bacteriol. 181: 1739–1747. PMID 10074065.
  2. Dolzan, M.; Johansson, K.; Roig-Zamboni, V.; Campanacci, V.; Tegoni, M.; Schneider, G.; Cambillau, C. (2004). "Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function". FEBS Lett. 571: 141–146. doi:10.1016/j.febslet.2004.06.075. PMID 15280032.
  3. Schuster, J.; Knill, T.; Reichelt, M.; Gershenzon, J.; Binder, S. (2006). "Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis". Plant Cell. 18: 2664–2679. doi:10.1105/tpc.105.039339. PMID 17056707.
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