Molybdopterin synthase sulfurtransferase
| Molybdopterin synthase sulfurtransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.1.11 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Molybdopterin synthase sulfurtransferase (EC 2.8.1.11, adenylyltransferase and sulfurtransferase MOCS3, Cnx5 (gene), molybdopterin synthase sulfurylase) is an enzyme with systematic name persulfurated L-cysteine desulfurase:(molybdopterin-synthase sulfur-carrier protein)-Gly-Gly sulfurtransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + cysteine desulfurase
The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of molybdopterin synthase.
References
- ↑ Matthies, A.; Nimtz, M.; Leimkuhler, S. (2005). "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry". Biochemistry. 44: 7912–7920. doi:10.1021/bi0503448. PMID 15910006.
- ↑ Leimkuhler, S.; Rajagopalan, K.V. (2001). "A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli". J. Biol. Chem. 276 (25): 22024–22031. doi:10.1074/jbc.M102072200. PMID 11290749.
- ↑ Hanzelmann, P.; Dahl, J.U.; Kuper, J.; Urban, A.; Muller-Theissen, U.; Leimkuhler, S.; Schindelin, H. (2009). "Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains". Protein Sci. 18 (12): 2480–2491. doi:10.1002/pro.260. PMID 19798741.
- ↑ Dahl, J.U.; Urban, A.; Bolte, A.; Sriyabhaya, P.; Donahue, J.L.; Nimtz, M.; Larson, T.J.; Leimkuhler, S. (2011). "The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli". J. Biol. Chem. 286 (41): 35801–35812. doi:10.1074/jbc.M111.282368. PMID 21856748.
External links
- Molybdopterin synthase sulfurtransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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