Mycothiol synthase

Mycothiol synthase
Identifiers
EC number 2.3.1.189
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Mycothiol synthase (EC 2.3.1.189, MshD) is an enzyme with systematic name acetyl-CoA:desacetylmycothiol O-acetyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

desacetylmycothiol + acetyl-CoA CoA + mycothiol

This enzyme catalyses the last step in the biosynthesis of mycothiol

References

  1. Spies, H.S.; Steenkamp, D.J. (1994). "Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis". Eur. J. Biochem. 224: 203–213. doi:10.1111/j.1432-1033.1994.tb20013.x. PMID 8076641.
  2. Koledin, T.; Newton, G.L.; Fahey, R.C. (2002). "Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes". Arch. Microbiol. 178: 331–337. doi:10.1007/s00203-002-0462-y. PMID 12375100.
  3. Vetting, M.W.; Roderick, S.L.; Yu, M.; Blanchard, J.S. (2003). "Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases". Protein Sci. 12: 1954–1959. doi:10.1110/ps.03153703. PMID 12930994.
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