Neomycin C transaminase

Neomycin C transaminase
Identifiers
EC number 2.6.1.95
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Neomycin C transaminase (EC 2.6.1.95, neoN (gene)) is an enzyme with systematic name 2-oxoglutarate:neomycin C aminotransferase.[1][2] This enzyme catalyses the following chemical reaction

neomycin C + 2-oxoglutarate 6'''-deamino-6-oxoneomycin C + L-glutamate

The reaction occurs in vivo in the opposite direction.

References

  1. Huang, F.; Spiteller, D.; Koorbanally, N.A.; Li, Y.; Llewellyn, N.M.; Spencer, J.B. (2007). "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8: 283–288. doi:10.1002/cbic.200600371. PMID 17206729.
  2. Clausnitzer, D.; Piepersberg, W.; Wehmeier, U.F. (2011). "The oxidoreductases LivQ and NeoQ are responsible for the different 6-modifications in the aminoglycosides lividomycin and neomycin". J. Appl. Microbiol. 111: 642–651. doi:10.1111/j.1365-2672.2011.05082.x. PMID 21689223.
This article is issued from Wikipedia - version of the 5/22/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.