PFKFB2

PFKFB2
Identifiers
Aliases PFKFB2, PFK-2/FBPase-2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
External IDs MGI: 107815 HomoloGene: 88554 GeneCards: PFKFB2
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

5208

18640

Ensembl

ENSG00000123836

ENSMUSG00000026409

UniProt

O60825

P70265

RefSeq (mRNA)

NM_001018053
NM_006212

NM_001162415
NM_001162416
NM_008825

RefSeq (protein)

NP_001018063.1
NP_006203.2

NP_032851.2

Location (UCSC) Chr 1: 207.03 – 207.08 Mb Chr 1: 130.69 – 130.73 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene.[3]

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.[3]

Interactions

PFKFB2 has been shown to interact with YWHAQ.[4]

References

Further reading


This article is issued from Wikipedia - version of the 6/4/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.