PIGW

PIGW
Identifiers
Aliases	PIGW, Gwt1, HPMRS5, phosphatidylinositol glycan anchor biosynthesis class W
External IDs	MGI: 1917575 HomoloGene: 6243 GeneCards: PIGW
Gene ontology Molecular function • transferase activity, transferring acyl groups • transferase activity • O-acyltransferase activity Cellular component • membrane • endoplasmic reticulum membrane • integral component of membrane • endoplasmic reticulum Biological process • GPI anchor biosynthetic process • GPI anchor metabolic process • protein localization to plasma membrane • preassembly of GPI anchor in ER membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	284098	70325
Ensembl	n/a	ENSMUSG00000045140
UniProt	Q7Z7B1	Q8C398
RefSeq (mRNA)	NM_178517	NM_001077636 NM_027388
RefSeq (protein)	NP_848612.2	NP_001071104.1 NP_081664.2
Location (UCSC)	Chr 17: 36.54 – 36.54 Mb	Chr 11: 84.88 – 84.88 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Phosphatidylinositol glycan anchor biosynthesis class W is a protein that in humans is encoded by the PIGW gene. ^[3]

Function

Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 [PubMed 14517336]).

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Phosphatidylinositol glycan anchor biosynthesis class W". Retrieved 2016-10-29.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.