Phosphatidylinositol 3-phosphate

Phosphatidylinositol 3-phosphate

Names
Other names sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate
Identifiers
PubChem	6857403
Properties
Chemical formula	C11H20O16P2
Molar mass	470.214 g/mol, neutral with fatty acid composition - 18:0, 20:4
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) is a phospholipid found in cell membranes that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes. It is the product of both the class II and III phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol.^[1]

PtdIns3P is dephosphorylated by the myotubularin family of phosphatases, on the D3 position of the inositol ring, and can be converted to PtdIns(3,5)P₂ by the lipid kinase PIKfyve.

Both FYVE domains and PX domains – found in proteins such as SNX1, Hrs, and EEA1 – bind to PtdIns3P.

The majority of PtdIns3P appears to be constitutively synthesised by the class III PI 3-kinase, Vps34, at endocytic membranes. Class II PI 3-kinases also appear to synthesise PtdIns3P, their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3P may be synthesised upon cell stimulation.

References

1. D J Gillooly; A Simonsen; H Stenmark (April 15, 2001). "Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins". Biochem J. 355 (Pt 2): 249–258. doi:10.1042/0264-6021:3550249. PMC 1221734. PMID 11284710.