Phosphopeptide

Phosphopeptides are modified self antigens which may induce an immune response.

Phosphorylation of serine and threonine residues is conserved during MHC class I and MHC class II antigen processing. Phosphopeptides are thus displayed on the surface of cells. As modified self antigens,they are potentially immunogenic when compared to unmodified self proteins as the immune cells (T-cells) which recognise them are possibly not subject to central tolerance mechanisms.

Immunology: lymphocytic adaptive immune system and complement

Lymphoid

Antigens	Antigen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Antigen presentation/Professional APCs: Dendritic cell Macrophage B cell Immunogen

Antibodies	Antibody Monoclonal antibodies Polyclonal antibodies Autoantibody Microantibody Polyclonal B cell response Allotype Isotype Idiotype Immune complex Paratope

Immunity vs. tolerance	action: Immunity Autoimmunity Alloimmunity Allergy Hypersensitivity Inflammation Cross-reactivity inaction: Tolerance Central Peripheral Clonal anergy Clonal deletion Tolerance in pregnancy Immunodeficiency

Immunogenetics	Affinity maturation (Somatic hypermutation Clonal selection) V(D)J recombination Junctional diversity Immunoglobulin class switching MHC/HLA

Lymphocytes

Substances

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