Protein geranylgeranyltransferase type I
| CAAX-protein geranylgeranyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.59 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a protein geranylgeranyltransferase type I (EC 2.5.1.59) is an enzyme that catalyzes the chemical reaction
- geranylgeranyl diphosphate + protein-cysteine S-geranylgeranyl-protein + diphosphate
Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and protein-cysteine, whereas its two products are S-geranylgeranyl-protein and diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl-diphosphate:protein-cysteine geranyltransferase. Other names in common use include GGTase-I, and GGTaseI.
Structural studies
As of late 2007, 17 structures have been solved for this class of enzymes, with PDB accession codes 1S63, 1S64, 1SA4, 1SA5, 1TNB, 1TNO, 1TNU, 1TNY, 1TNZ, 1X81, 2BED, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, and 2IEJ.
References
- Casey PJ, Seabra MC (1996). "Protein prenyltransferases". J. Biol. Chem. 271 (10): 5289–92. doi:10.1074/jbc.271.10.5289. PMID 8621375.
- Zhang FL, Casey PJ. "Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I". Biochem. J. 320 (Pt 3): 925–32. PMC 1218017
. PMID 9003382. - Sinnott, M. (Ed.), Comprehensive Biological Catalysis. A Mechanistic Reference, vol. 1, Academic Press, San Diego, CA, 1998, p. 31-118.