Protein geranylgeranyltransferase type II
| Rab-protein geranylgeranyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.60 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a protein geranylgeranyltransferase type II (EC 2.5.1.60) is an enzyme that catalyzes the chemical reaction
- geranylgeranyl diphosphate + protein-cysteine S-geranylgeranyl-protein + diphosphate
Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and protein-cysteine, whereas its two products are S-geranylgeranyl-protein and diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl-diphosphate:protein-cysteine geranyltransferase. Other names in common use include GGTaseII, Rab geranylgeranyltransferase, RabGGTase, geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-, and cysteine geranyltransferase.
References
- Casey PJ, Seabra MC (1996). "Protein prenyltransferases". J. Biol. Chem. 271 (10): 5289–92. doi:10.1074/jbc.271.10.5289. PMID 8621375.
- Wilson AL, Erdman RA, Castellano F, Maltese WA. "Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases". Biochem. J. 333 (Pt 3): 497–504. PMC 1219609
. PMID 9677305. - Zhang H, Seabra MC, Deisenhofer J (2000). "Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution". Structure. Fold. Des. 8 (3): 241–51. doi:10.1016/S0969-2126(00)00102-7. PMID 10745007.
- Thoma NH, Niculae A, Goody RS, Alexandrov K (2001). "Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate". J. Biol. Chem. 276 (52): 48631–6. doi:10.1074/jbc.M106470200. PMID 11591706.
- Alexandrov K; Niculae, A; Kalinin, A; Thomä, NH; Sidorovitch, V; Goody, RS; Alexandrov, K (2002). "In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex". Protein. Expr. Purif. 25 (1): 23–30. doi:10.1006/prep.2001.1605. PMID 12071695.
- Sinnott, M. (Ed.), Comprehensive Biological Catalysis. A Mechanistic Reference, vol. 1, Academic Press, San Diego, CA, 1998, p. 31-118.
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