RNF12

RLIM
Identifiers
Aliases	RLIM, NY-REN-43, RNF12, ring finger protein, LIM domain interacting
External IDs	MGI: 1342291 HomoloGene: 7920 GeneCards: RLIM
Gene ontology Molecular function • zinc ion binding • ligase activity • transcription corepressor activity • metal ion binding • ubiquitin-protein transferase activity • ubiquitin protein ligase activity Cellular component • transcriptional repressor complex • nucleus • cytosol • cytoplasm • nucleoplasm Biological process • negative regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • random inactivation of X chromosome • ubiquitin-dependent protein catabolic process • transcription, DNA-templated • protein ubiquitination • negative regulation of sequence-specific DNA binding transcription factor activity • regulation of transcription, DNA-templated • regulation of dosage compensation by inactivation of X chromosome • proteasome-mediated ubiquitin-dependent protein catabolic process • protein polyubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51132	19820
Ensembl	ENSG00000131263	ENSMUSG00000056537
UniProt	Q9NVW2	Q9WTV7
RefSeq (mRNA)	NM_183353 NM_016120	NM_011276
RefSeq (protein)	NP_057204.2 NP_899196.1	NP_035406.3
Location (UCSC)	Chr X: 74.59 – 74.61 Mb	Chr X: 103.96 – 103.98 Mb
PubMed search	[1]	[2]
Wikidata

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E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.^[3][4]

Function

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.^[4]

Interactions

RNF12 has been shown to interact with Estrogen receptor alpha.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
4. "Entrez Gene: RNF12 ring finger protein 12".
5. Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I (Jan 2009). "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer". Cancer Res. 69 (1): 128–36. doi:10.1158/0008-5472.CAN-08-1630. PMC 2713826. PMID 19117995.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Hiratani I, Yamamoto N, Mochizuki T, Ohmori SY, Taira M (2003). "Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions". Development. 130 (17): 4161–75. doi:10.1242/dev.00621. PMID 12874135.
• Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors". Nature. 416 (6876): 99–103. doi:10.1038/416099a. PMID 11882901.
• Ostendorff HP, Bossenz M, Mincheva A, Copeland NG, Gilbert DJ, Jenkins NA, Lichter P, Bach I (2000). "Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors". Genomics. 69 (1): 120–30. doi:10.1006/geno.2000.6311. PMID 11013082.
• Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247.