Shigekazu Nagata
| Shigekazu Nagata | |
|---|---|
| Native name | 長田 重一 |
| Born |
1949 Kanazawa, Ishikawa, Japan |
| Nationality | Japanese |
| Fields |
Molecular biology Immunology Oncology |
| Institutions |
Kyoto University Osaka University Osaka Bioscience Institute University of Tokyo University of Zurich |
| Alma mater | University of Tokyo |
| Doctoral advisor | Yoshito Kajiro |
| Known for |
Interferon Granulocyte colony-stimulating factor Fas ligand Fas receptor Apoptosis |
| Notable awards |
Robert Koch Prize Imperial Prize of the Japan Academy Asahi Prize (1997) |
Shigekazu Nagata (長田 重一 Nagata Shigekazu, born 1949) is a Japanese molecular biologist, best known for research on apoptosis, the process of programmed cell death occurring in multi-cellular organisms.[1]
Contribution
Nagata identified Interferon in 1980[2] and Granulocyte colony-stimulating factor in 1986.[3] He also identified a death factor (Fas receptor) in 1991[4] and its ligand (Fas ligand) in 1993,[5] and elucidated their physiological and pathological roles in Apoptosis.[6]
Biography
Nagata received his PhD from the University of Tokyo in 1977.[7] He served as a postdoctoral fellow under Charles Weissmann at University of Zurich, where he worked on sequencing the cDNA of Interferon gene between 1977 and 1981.[7] He was Assistant professor at the Institute of Medical Science, the University of Tokyo between 1982 and 1987, and Head of Department of molecular biology at Osaka Bioscience Institute between 1987 and 1998, and Professor of genetics at Osaka University Medical School between 1995 and 2007, before being appointed as Professor of medical chemistry at the Graduate School of Medicine, Kyoto University in 2007.[7] He was elected a member of the Japan Academy in 2010.
Honors and awards
- 1994: Emil von Boehring Prize, Marburg University (Marburg, Germany)[7]
- 1995: Robert Koch Prize, Koch Foundation (Bonn, Germany)[7]
- 1996: Prix Lacassagne, French Cancer League (Paris, France)[7]
- 1998: Asahi Prize, Asahi Shimbun (Tokyo, Japan)[7]
- 2000: Imperial Prize of the Japan Academy, Japan Academy (Tokyo, Japan)[7]
- 2001: Person of Cultural Merit, Japanese Government (Japan)[7]
- 2004: Cell Death Society Prize, International Cell Death Society (Dublin, Ireland)[7]
- 2012: Honorary Doctorate, University of Zurich (Zurich, Switzerland)[7]
- 2012: Tomizo Yoshida Award, Japanese Cancer Association and Tomizo Yoshida Memorial Hall (Fukushima, Japan)
- 2012: Debrecen Award for Molecular Medicine[8]
- 2013: Keio Medical Science Prize (with Victor Ambros), Keio University (Tokyo, Japan)[9]
- 2015: Members of the United States National Academy of Sciences
References
- ↑ Cyranoski, D. (2001). "Shigekazu Nagata". Nature Medicine. 7 (7): 759. doi:10.1038/89860. PMID 11433328.
- ↑ Nagata, S; Taira, H; Hall, A; Johnsrud, L; Streuli, M; Ecsödi, J; Boll, W; Cantell, K; Weissmann, C (1980). "Synthesis in E. Coli of a polypeptide with human leukocyte interferon activity". Nature. 284 (5754): 316–20. doi:10.1038/284316a0. PMID 6987533.
- ↑ Nagata, S; Tsuchiya, M; Asano, S; Kaziro, Y; Yamazaki, T; Yamamoto, O; Hirata, Y; Kubota, N; Oheda, M; Nomura, H; Ono, Masayoshi (1986). "Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor". Nature. 319 (6052): 415–8. doi:10.1038/319415a0. PMID 3484805.
- ↑ Itoh, N; Yonehara, S; Ishii, A; Yonehara, M; Mizushima, S; Sameshima, M; Hase, A; Seto, Y; Nagata, S (1991). "The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis". Cell. 66 (2): 233–43. doi:10.1016/0092-8674(91)90614-5. PMID 1713127.
- ↑ Suda, T; Takahashi, T; Golstein, P; Nagata, S (1993). "Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family". Cell. 75 (6): 1169–78. doi:10.1016/0092-8674(93)90326-L. PMID 7505205.
- ↑ "F1000 faculty". Faculty of 1000. Faculty of 1000. Retrieved 28 January 2014.
- 1 2 3 4 5 6 7 8 9 10 11 CV of Shigekazu Nagata, JST (pdf)
- ↑ "Debrecen Award for Molecular Medicine". University of Debrecen. Retrieved 7 January 2015.
- ↑ "The 2013 Keio Medical Science Prize Awardees". The Keio Medical Sciences Prize. Keio University. Retrieved 18 January 2014.