Site-specific DNA-methyltransferase (cytosine-N4-specific)
| Site-specific DNA-methyltransferase (cytosine-N4-specific) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.113 | ||||||||
| CAS number | 169592-50-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Site-specific DNA-methyltransferase (cytosine-N4-specific) (EC 2.1.1.113, modification methylase, restriction-modification system, DNA[cytosine-N4]methyltransferase, m4C-forming MTase, S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + DNA cytosine S-adenosyl-L-homocysteine + DNA N4-methylcytosine
This is a large group of enzymes.[5]
References
- ↑ Kessler, C.; Manta, V. (1990). "Specificity of restriction endonucleases and DNA modification methyltransferases: a review". Gene. 92: 1–248. doi:10.1016/0378-1119(90)90486-B. PMID 2172084.
- ↑ Klimasauskas, S.; Timinskas, A.; Menkevicius, S.; Butkiene, D.; Butkus, V.; Janulaitis, A. (1989). "Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases". Nucleic Acids Res. 17: 9823–9832. doi:10.1093/nar/17.23.9823. PMID 2690010.
- ↑ Roberts, R.J. (1990). "Restriction enzymes and their isoschizomers". Nucleic Acids Res. 18: 2331–2365. doi:10.1093/nar/18.suppl.2331. PMID 2159140.
- ↑ Yuan, R. (1981). "Structure and mechanism of multifunctional restriction endonucleases". Annu. Rev. Biochem. 50: 285–319. doi:10.1146/annurev.bi.50.070181.001441. PMID 6267988.
- ↑ R.J. Roberts. "A complete listing of all of these enzymes".
See also
External links
- Site-specific DNA-methyltransferase (cytosine-N4-specific) at the US National Library of Medicine Medical Subject Headings (MeSH)
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