Small temporal RNA

Small temporal RNA (abbreviated stRNA) regulates gene expression during roundworm development by preventing the mRNAs they bind from being translated.^[1] In contrast to siRNA, stRNAs downregulate expression of target RNAs after translation initiation without affecting mRNA stability.^[2] Nowadays, stRNAs are better known as miRNAs.

stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 and members of the RDE-1/AGO1 family of proteins, which are better known for their roles in RNA interference (RNAi). stRNAs may function to control temporal identity during development in C. elegans and other organisms.^[3]

References

↑ Science, vol. 293, no. 5531, pp. 811-813 (August 3, 2001).
↑ Grosshans H, Slack FJ (2002). "Micro-RNAs : small is plentiful". J Cell Biol. 156 (1): 17–22. doi:10.1083/jcb.200111033. PMC 2173595. PMID 11781331.
↑ Banerjee D, Slack F (February 2002). "Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression". BioEssays. 24 (2): 119–29. doi:10.1002/bies.10046. PMID 11835276.

Types of RNA

Protein synthesis	Messenger RNA Ribosomal RNA Signal recognition particle RNA Transfer RNA Transfer-messenger RNA

RNA processing	Small nuclear RNA Small nucleolar RNA Guide RNA RNase P RNase MRP Y RNA

Gene regulation	Antisense RNA Cis-natural antisense transcript CRISPR RNA Long noncoding RNA MicroRNA Piwi-interacting RNA Repeat-associated siRNA Small interfering RNA Small temporal RNA Trans-acting siRNA

Cis-regulatory elements	Riboswitch SECIS element

Parasites	Retrotransposon Reverse transcribing virus RNA virus Viroid

Other	Telomerase RNA Vault RNA

Types of nucleic acids

Constituents

Ribonucleic acids
(coding, non-coding)

Translational	Messenger precursor, heterogenous nuclear Transfer Ribosomal Transfer-messenger

Regulatory	Interferential Micro Small interfering Piwi-interacting Antisense Processual Small nuclear Small nucleolar Small Cajal Body RNAs Y RNA Enhancer RNAs

Others	Guide Ribozyme Small hairpin Small temporal Trans-acting small interfering Subgenomic messenger

Deoxyribonucleic acids

Analogues

Cloning vectors

Phagemid
Plasmid
Lambda phage
Cosmid
Fosmid
Artificial chromosomes
- P1-derived
- Bacterial
- Yeast
- Human

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