Sulfametrole

Sulfametrole
Clinical data


AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	J01EE03 (WHO) (with trimethoprim)
Legal status
Legal status	℞ (Prescription only)
Identifiers
IUPAC name 4-amino-N-(4-methoxy-1,2,5-thiadiazol-3-yl)benzenesulfonamide
CAS Number	32909-92-5
PubChem (CID)	64939
ChemSpider	58466
UNII	F5AK41IPQG^Y
KEGG	D08541^Y
ChEBI	CHEBI:88258^Y
ECHA InfoCard	100.046.611
Chemical and physical data
Formula	C₉H₁₀N₄O₃S₂
Molar mass	286.33 g/mol
3D model (Jmol)	Interactive image
SMILES COc1c(nsn1)NS(=O)(=O)c2ccc(cc2)N
InChI InChI=1S/C9H10N4O3S2/c1-16-9-8(11-17-12-9)13-18(14,15)7-4-2-6(10)3-5-7/h2-5H,10H2,1H3,(H,11,13) Key:IZOYMGQQVNAMHS-UHFFFAOYSA-N
(verify)

Sulfametrole (INN) is a sulfonamide antibacterial.

It can be given with trimethoprim.^[1]

References

↑ Plummer FA, Nsanze H, D'Costa LJ, et al. (July 1983). "Single-dose therapy of chancroid with trimethoprim-sulfametrole". N. Engl. J. Med. 309 (2): 67–71. doi:10.1056/NEJM198307143090202. PMID 6343878.

Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)

Short- acting	Sulfaisodimidine Sulfamethizole Sulfadimidine Sulfapyridine Sulfafurazole Sulfanilamide Prontosil Sulfathiazole Sulfathiourea

Intermediate- acting	Sulfamethoxazole Sulfadiazine^# Sulfamoxole

Long- acting	Sulfadimethoxine Sulfadoxine Sulfalene Sulfametomidine Sulfametoxydiazine Sulfamethoxypyridazine Sulfaperin Sulfamerazine Sulfaphenazole Sulfamazone

Other/ungrouped	Sulfacetamide Sulfadicramide Sulfametrole

Combinations

2nd g.	Ciprofloxacin^# Ofloxacin Enoxacin^‡ Fleroxacin^‡ Lomefloxacin^‡ Nadifloxacin^‡ Norfloxacin^‡ Pefloxacin^‡ Rufloxacin^‡

3rd g.	Levofloxacin Balofloxacin^‡ Grepafloxacin^‡ Pazufloxacin^‡ Sparfloxacin^‡ Temafloxacin^‡ Tosufloxacin^‡

4th g.	Besifloxacin Gatifloxacin Finafloxacin Gemifloxacin Moxifloxacin Clinafloxacin^† Garenoxacin^‡ Prulifloxacin^‡ Sitafloxacin^‡ Trovafloxacin^‡/Alatrofloxacin^‡

Vet.	Danofloxacin Difloxacin Enrofloxacin Ibafloxacin Marbofloxacin Orbifloxacin Pradofloxacin Sarafloxacin

Newer non-fluorinated

Related (DG)

Nitro- imidazole derivatives	Metronidazole^# Tinidazole Ornidazole

Nitrofuran derivatives	Nitrofurantoin^# Furazolidone^‡ Nifurtoinol

RNA synthesis

Rifamycins/ RNA polymerase	Rifampicin^# Rifabutin Rifapentine Rifaximin Rifalazil^§

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