TRNAMet cytidine acetyltransferase

TRNAMet cytidine acetyltransferase (EC 2.3.1.193, YpfI, TmcA) is an enzyme with systematic name acetyl-CoA:(elongator tRNAMet)-cytidine³⁴ N⁴-acetyltransferase (ATP-hydrolysing).^[1]^[2] This enzyme catalyses the following chemical reaction

[elongator tRNAMet]-cytidine³⁴ + ATP + acetyl-CoA

\rightleftharpoons

CoA + [elongator tRNAMet]-N⁴-acetylcytidine³⁴ + ADP + phosphate

The enzyme acetylates the wobble base C³⁴ of the CAU anticodon of elongation-specific tRNAMet.

References

↑ Ikeuchi, Y.; Kitahara, K.; Suzuki, T. (2008). "The RNA acetyltransferase driven by ATP hydrolysis synthesizes N⁴-acetylcytidine of tRNA anticodon". EMBO J. 27: 2194–2203. doi:10.1038/emboj.2008.154. PMID 18668122.
↑ Chimnaronk, S.; Suzuki, T.; Manita, T.; Ikeuchi, Y.; Yao, M.; Suzuki, T.; Tanaka, I. (2009). "RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon". EMBO J. 28: 1362–1373. doi:10.1038/emboj.2009.69. PMID 19322199.

Transferases: acyltransferases (EC 2.3)

2.3.1: other than amino-acyl groups	acetyltransferases: Acetyl-Coenzyme A acetyltransferase N-Acetylglutamate synthase Choline acetyltransferase Dihydrolipoyl transacetylase Acetyl-CoA C-acyltransferase Beta-galactoside transacetylase Chloramphenicol acetyltransferase N-acetyltransferase Serotonin N-acetyl transferase HGSNAT ARD1A Histone acetyltransferase P300/CBP NAT2 palmitoyltransferases: Carnitine O-palmitoyltransferase CPT1 CPT2 Serine C-palmitoyltransferase SPTLC1 SPTLC2 other: Acyltransferase like 2 Aminolevulinic acid synthase Beta-ketoacyl-ACP synthase Glyceronephosphate O-acyltransferase Lecithin—cholesterol acyltransferase Glycerol-3-phosphate O-acyltransferase 1-acylglycerol-3-phosphate O-acyltransferase 2-acylglycerol-3-phosphate O-acyltransferase ABHD5

2.3.2: Aminoacyltransferases	Gamma-glutamyl transpeptidase Peptidyl transferase Transglutaminase Tissue transglutaminase Keratinocyte transglutaminase Factor XIII

2.3.3: converted into alkyl on transfer	Citrate synthase ATP citrate lyase HMG-CoA synthase Malate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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