Trans,polycis-decaprenyl diphosphate synthase

Trans,polycis-decaprenyl diphosphate synthase (EC 2.5.1.86, Rv2361c, (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase) is an enzyme with systematic name (2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesylcistransferase (adding 7 isopentenyl units) .^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate

\rightleftharpoons

7 diphosphate + trans,octacis-decaprenyl diphosphate

The enzyme is involved in the biosynthesis of decaprenyl phosphate.

References

↑ Kaur, D.; Brennan, P.J.; Crick, D.C. (2004). "Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis". J. Bacteriol. 186 (22): 7564–7570. doi:10.1128/JB.186.22.7564-7570.2004. PMC 524883. PMID 15516568.
↑ Wang, W.; Dong, C.; McNeil, M.; Kaur, D.; Mahapatra, S.; Crick, D.C.; Naismith, J.H. (2008). "The structural basis of chain length control in Rv1086". J. Mol. Biol. 381 (1): 129–140. doi:10.1016/j.jmb.2008.05.060. PMC 2527485. PMID 18597781.
↑ Crick, D.C.; Schulbach, M.C.; Zink, E.E.; Macchia, M.; Barontini, S.; Besra, G.S.; Brennan, P.J. (2000). "Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis". J. Bacteriol. 182 (20): 5771–5778. doi:10.1128/JB.182.20.5771-5778.2000. PMC 94699. PMID 11004176.

External links

Trans,polycis-decaprenyl diphosphate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferases: alkyl and aryl (EC 2.5)

2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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