Trans-hexaprenyltranstransferase
| trans-hexaprenyltranstransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.30 | ||||||||
| CAS number | 74506-59-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a trans-hexaprenyltranstransferase (EC 2.5.1.30) is an enzyme that catalyzes the chemical reaction
- all-trans-hexaprenyl diphosphate + isopentenyl diphosphate diphosphate + all-trans-heptaprenyl diphosphate
Thus, the two substrates of this enzyme are all-trans-hexaprenyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-heptaprenyl diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase. Other names in common use include all-trans-heptaprenyl-diphosphate synthase, heptaprenyl pyrophosphate synthase, heptaprenyl diphosphate synthase, and heptaprenyl pyrophosphate synthetase. This enzyme participates in biosynthesis of steroids.
Structural studies
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 2E8T, 2E8U, 2E8V, 2E8W, 2E8X, 2E90, 2E91, 2E92, 2E93, 2E94, and 2E95.
References
- Takahashi I, Ogura K, Seto S (1980). "Heptaprenyl pyrophosphate synthetase from Bacillus subtilis". J. Biol. Chem. 255 (10): 4539–43. PMID 6768722.